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KMID : 1134820230520080780
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Journal of the Korean Society of Food Science and Nutrition
2023 Volume.52 No. 8 p.780 ~ p.787
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Antioxidant Activity of Ethyl Acetate Fraction of Ulmus davidiana var. japonica in Caenorhabditis elegans
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Mun Ji-Su
Kim Hyeoun-Ji
Moon Hae-Ju
Oh Suk-Heung
Kim Jun-Hyeong
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Abstract
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Oxidation occurs constantly in the body to supply energy. A large quantity of free radicals are produced during this process. When free radicals are in excess, they can cause various diseases. The free radicals generate some oxygen as reactive oxygen species during the respiratory metabolic process in the mitochondria in cells. This causes an increase in the quantum of reactive oxygen species (ROS) that reacts with the DNA, proteins, and lipids. This promotes aging and can also cause cancer, heart disease, and arteriosclerosis. It is known that the oxidative stress caused by a large amount of reactive oxygen can be reduced by antioxidants. Hence, interest in developing antioxidants is increasing. There is an increase in the need for antioxidants from natural sources as they offer economic feasibility combined with safety in humans. In this study, the antioxidant efficacy of the ethyl acetate fraction of Ulmus davidiana var. japonica was evaluated in vitro by measuring its 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and superoxide scavenging ability, and was observed to be significant. The ethyl acetate fraction produced, and the antioxidant mechanisms were studied using the nematodes. the activity of the antioxidant enzymes, superoxide dismutase (SOD) and catalase, and the ability to inhibit the accumulation of ROS in cells were confirmed in the nematodes cells.
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KEYWORD
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antioxidant, Caenorhabditis elegans, SOD, ROS, Ulmus davidiana var. japonica
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